| 言語種別 | 英語 |
|---|---|
| 発行・発表の年月 | 2020/08/18 |
| 形態種別 | 学術雑誌 |
| 査読 | 査読あり |
| 標題 | Multicoding in neural information transfer suggested by mathematical analysis of the frequency‑dependent synaptic plasticity in vivo |
| 執筆形態 | 共著 |
| 掲載誌名 | Scientific Reports |
| 掲載区分 | 国外 |
| 出版社・発行元 | Springer Nature |
| 巻・号・頁 | 10(13974) |
| 総ページ数 | 18 |
| 著者・共著者 | Katsuhiko Hata, Osamu Araki, Osamu Yokoi, Tatsumi Kusakabe, Yoshio Yamamoto,
Susumu Ito & Tetsuro Nikuni |
| 概要 | The importance of the firing frequency in synaptic plasticity in vivo has been recognized again. However, little is understood about how the frequency-dependent synaptic plasticity (FDP) is regulated in vivo. Here, we focused on the presynaptic input pattern, the intracellular calcium decay time constants, and the background synaptic activity, which vary depending on neuron types and the anatomical and physiological environment in the brain. By analyzing a calcium-based model, we found that the synaptic weight differs depending on these factors characteristic in vivo, even if neurons receive the same input rate. This finding suggests the involvement of multifaceted factors other than input frequency in FDP and even neural coding in vivo. |